Department of Physiology, Keimyung University School of Medicine, Daegu 42601, Korea.
BMB Rep. 2022 Oct;55(10):481-487. doi: 10.5483/BMBRep.2022.55.10.124.
Over the past few years, hydrogen sulfide (HS) has been shown to exert several biological functions in mammalian. The endogenous production of HS is mainly mediated by cystathione β-synthase, cystathione γ-lyase and 3-mercaptopyruvate sulfur transferase. These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, HS is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis and liver cancer. Targeting HS-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of HS in liver disease and summarized recent characterized role of HS in several cellular process of the liver. [BMB Reports 2022; 55(10): 481-487].
在过去的几年中，已经证明硫化氢 (HS) 在哺乳动物中具有多种生物学功能。 HS 的内源性产生主要由胱硫醚 β-合酶、胱硫醚 γ-裂合酶和 3-巯基丙酮酸硫转移酶介导。这些酶在肝组织中广泛表达，并通过作用于多种分子靶点来调节肝功能。作为肝功能的重要调节剂，HS 参与了多种肝脏疾病的发病机制，如非酒精性脂肪性肝炎和肝癌。针对 HS 生成酶可能是控制肝脏疾病的一种治疗策略。本综述描述了 HS 在肝脏疾病中的作用，并总结了 HS 在肝脏的几个细胞过程中的作用。[BMB 报告 2022;55(10):481-487]。
