通过分子内羟胺甲基化策略构建石松生物碱石松定 H 的氮杂环辛烷（氮杂环辛烷）部分。
Construction of the azocane (azacyclooctane) moiety of the Lycopodium alkaloid lycopladine H via an intramolecular hydroaminomethylation strategy.
机构信息
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
出版信息
Org Lett. 2012 Apr 20;14(8):2172-5. doi: 10.1021/ol3007277. Epub 2012 Apr 9.
PMID:22486178
Abstract
An efficient synthetic strategy has been developed for annulation of an azocane ring onto a bicyclo[2.2.2]octane scaffold via an intramolecular hydroaminomethylation protocol to generate an advanced intermediate bearing three of the four rings of the structurally unique Lycopodium alkaloid lycopladine H (1).
摘要
已经开发出一种有效的合成策略，通过分子内羟胺甲基化反应将氮杂环丙烷环环合到双环[2.2.2]辛烷支架上，生成一个具有四个结构独特石松生物碱石松定 H（1）环中三个环的高级中间体。
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