State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Org Lett. 2012 May 4;14(9):2293-5. doi: 10.1021/ol3007138. Epub 2012 Apr 12.
A concise construction of the 6/6/5 tricyclic core of Lycopodium alkaloid palhinine A (1) has been accomplished. The developed synthetic strategy featured a tandem oxidative dearomatization/intramolecular Diels-Alder reaction to construct C/D rings and an intramolecular 5-exo-trig radical cyclization to install the B ring of palhinine A (1). The developed approach paves the way for the total synthesis of palhinine A (1).
已经完成了石松生物碱 palhinine A（1）的 6/6/5 三环核心的简洁构建。所开发的合成策略的特点是串联氧化去芳构化/分子内 Diels-Alder 反应构建 C/D 环和分子内 5-endo-三键自由基环化以安装 palhinine A（1）的 B 环。所开发的方法为 palhinine A（1）的全合成铺平了道路。
