Juliá-Serdá Gabriel, Cabrera-Navarro Pedro, Acosta-Fernández Orlando, Martín-Pérez Pedro, García-Bello Miguel A, Antó-Boqué Josep
Department of Pulmonology, University of Las Palmas, Las Palmas de Gran Canaria, Canary Islands, Spain.
J Asthma. 2012 May;49(4):349-54. doi: 10.3109/02770903.2012.672611. Epub 2012 Apr 10.
There are no previous population-based studies assessing the prevalence of Blomia tropicalis (BT). This investigation analyzes the prevalence of sensitization to BT and its contribution to asthma and related diseases among young adults in the Canary Islands.
From a random sample of 9506 adults, aged between 20 and 44, who had previously answered a short respiratory questionnaire, a further 20% random sample was drawn. All participants filled in an extensive questionnaire, and they underwent spirometry and bronchial hyperresponsiveness (BHR) test and skin testing to several allergens as well as the determination of total IgE and specific IgE.
The prevalence of positive skin tests to BT was 13.8% (95% confidence interval [CI] 10.6-17.9%) and that of BT-specific IgE 17.9% (95% CI 14.2-24.5%). Sensitization to BT (positive skin tests or positive specific IgE) was 20.9% (95% CI 16.9-25.5%). Most of the subjects sensitized to BT were also sensitized to Dermatophagoides pteronissimus; however, only 7% displayed monosensitization to BT. Among subjects who exhibited BHR, sensitization to BT reached 46.7% (95% CI 32.7-60.9%), among those with asthma 50% (95% CI 26.8-73.2%), in subjects with rhinitis 37.2% (95% CI 28.1-47.6%), and in those suffering from dermatitis 25.9% (95% CI 18.7-34.5%). A strong association of BT sensitization with BHR and asthma before and after 15 years was found.
The prevalence of sensitization to BT among young adults in the Canary Islands is high, and it displays a close relationship with allergic respiratory diseases and dermatitis.
此前尚无基于人群的研究评估热带博宁螨（BT）的患病率。本调查分析了加那利群岛年轻人中对BT致敏的患病率及其对哮喘和相关疾病的影响。
从9506名年龄在20至44岁之间、此前回答过简短呼吸问卷的成年人中随机抽取20%的样本。所有参与者填写了一份详细问卷，并接受了肺活量测定、支气管高反应性（BHR）测试、针对多种过敏原的皮肤测试以及总IgE和特异性IgE的测定。
对BT皮肤测试呈阳性的患病率为13.8%（95%置信区间[CI]10.6 - 17.9%），BT特异性IgE的患病率为17.9%（95%CI 14.2 - 24.5%）。对BT致敏（皮肤测试阳性或特异性IgE阳性）为20.9%（95%CI 16.9 - 25.5%）。大多数对BT致敏的受试者也对粉尘螨致敏；然而，只有7%的人对BT呈单一致敏。在表现出BHR的受试者中，对BT致敏率达到46.7%（95%CI 32.7 - 60.9%），哮喘患者中为50%（95%CI 26.8 - 73.2%），鼻炎患者中为37.2%（95%CI 28.1 - 47.6%），皮炎患者中为25.9%（95%CI 18.7 - 34.5%）。发现BT致敏与15年前和15年后的BHR及哮喘之间存在密切关联。
加那利群岛年轻人中对BT致敏的患病率很高，且与过敏性呼吸道疾病和皮炎关系密切。
