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新西兰印裔和欧裔人群心血管疾病危险因素的聚类明显不同,但风险评分相似(PREDICT-14)。

Markedly different clustering of CVD risk factors in New Zealand Indian and European people but similar risk scores (PREDICT-14).

机构信息

Section of Epidemiology and Biostatistics, University of Auckland, New Zealand.

出版信息

Aust N Z J Public Health. 2012 Apr;36(2):141-4. doi: 10.1111/j.1753-6405.2011.00808.x. Epub 2012 Jan 2.

Abstract

OBJECTIVE

To compare the cardiovascular disease (CVD) risk profiles of Indian and European patients from routine primary care assessments in the northern region of New Zealand.

METHOD

Anonymous CVD risk profiles were extracted from PREDICT (a web-based decision support program) for Indian and European patients aged 35-74 years. Linear regression models were used to obtain mean differences adjusted for age, gender and deprivation.

RESULTS

At recruitment, Indian participants (n=8,830) were younger than Europeans (n=47,091), in keeping with national guidelines that recommend earlier CVD risk assessment for Indians. Compared with Europeans, a greater proportion of Indian participants lived in areas of higher deprivation and had a two to four-fold greater burden of diabetes in all age groups. Indian participants had a significantly lower proportion of smokers and a lower mean systolic blood pressure. The respective cardiovascular risk factor profiles lead to similar age-adjusted Framingham five-year CVD risk scores.

CONCLUSIONS AND IMPLICATIONS

National data sources indicate that there are higher rates of hospitalisations and deaths from CVD in Indians compared with Europeans. Our study found similar predicted CVD risk in these two populations despite markedly different clustering of risk factors, suggesting that the Framingham risk equation may underestimate risk in Indians. There is a need for better ethnicity coding to identify all South Asian ethnicities.

摘要

目的

比较新西兰北部地区常规初级保健评估中印度和欧洲患者的心血管疾病(CVD)风险概况。

方法

从 PREDICT(基于网络的决策支持程序)中提取年龄在 35-74 岁的印度和欧洲患者的匿名 CVD 风险概况。使用线性回归模型,针对年龄、性别和贫困程度进行调整,以获得平均差异。

结果

在招募时,印度参与者(n=8830)比欧洲人(n=47091)年轻,这符合建议对印度人进行更早 CVD 风险评估的国家指南。与欧洲人相比,更多的印度参与者居住在贫困程度较高的地区,并且在所有年龄段的糖尿病负担都增加了两到四倍。印度参与者的吸烟者比例明显较低,平均收缩压也较低。各自的心血管危险因素概况导致相似的年龄调整 Framingham 五年 CVD 风险评分。

结论和意义

国家数据表明,与欧洲人相比,印度人因 CVD 住院和死亡的比例更高。尽管危险因素的聚类明显不同,但我们的研究发现这两个人群的预测 CVD 风险相似,这表明 Framingham 风险方程可能低估了印度人的风险。需要更好的种族编码来识别所有南亚种族。

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