Department of Plastic and Hand Surgery, University of Freiburg Medical Center, D-79106 Freiburg, Germany.
Microvasc Res. 2012 Jul;84(1):81-5. doi: 10.1016/j.mvr.2012.03.010. Epub 2012 Mar 31.
Bone morphogenetic proteins (BMPs) and their receptors play important roles in cellular processes such as proliferation, differentiation, migration and cell survival. It was also demonstrated that BMPs are involved in vasculogenesis and angiogenesis. In this study, we investigated the expression profile of BMP receptors in human umbilical vein endothelial cells (HUVECs) and determined the effect of BMP-2 on proliferation, migration, invasion, cell survival and tube formation. HUVECs express the type I BMP receptors ALK2, ALK3 and ALK6 and the type II receptor BMPR-II. Treatment of HUVECs with recombinant human BMP-2 induced migration, invasion and tube formation of HUVECs without affecting proliferation and apoptosis. Our data suggest that BMP-2 represents a chemoattractant and proangiogenic factor for HUVECs.
骨形态发生蛋白（BMPs）及其受体在细胞增殖、分化、迁移和细胞存活等细胞过程中发挥重要作用。此外，BMPs 还参与血管发生和血管生成。在本研究中，我们研究了人脐静脉内皮细胞（HUVEC）中 BMP 受体的表达谱，并确定了 BMP-2 对增殖、迁移、侵袭、细胞存活和管形成的影响。HUVEC 表达 I 型 BMP 受体 ALK2、ALK3 和 ALK6 以及 II 型受体 BMPR-II。用重组人 BMP-2 处理 HUVEC 可诱导 HUVEC 的迁移、侵袭和管形成，而不影响增殖和凋亡。我们的数据表明，BMP-2 是 HUVEC 的趋化因子和促血管生成因子。
