非裔美国肾移植受者的 APOL1 基因型不影响 5 年移植物存活率。
The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival.
机构信息
Department of Medicine, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Am J Transplant. 2012 Jul;12(7):1924-8. doi: 10.1111/j.1600-6143.2012.04033.x. Epub 2012 Apr 4.
Abstract
Apolipoprotein L-1 (APOL1) gene variants are associated with end-stage renal disease in African Americans (AAs). Here we investigate the impact of recipient APOL1 gene distributions on kidney allograft outcomes. We conducted a retrospective analysis of 119 AA kidney transplant recipients, and found that 58 (48.7%) carried two APOL1 kidney disease risk variants. Contrary to the association seen in native kidney disease, there is no difference in allograft survival at 5-year posttransplant for recipients with high-risk APOL1 genotypes. Thus, we were able to conclude that APOL1 genotypes do not increase risk of allograft loss after kidney transplantations, and carrying 2 APOL1 risk alleles should not be an impediment to transplantation.
摘要
载脂蛋白 L-1 (APOL1) 基因变异与非裔美国人（AA）的终末期肾病有关。在这里，我们研究了受者 APOL1 基因分布对肾移植结局的影响。我们对 119 名 AA 肾移植受者进行了回顾性分析，发现 58 名（48.7%）携带 2 种 APOL1 肾病风险变异体。与在原发性肾病中观察到的关联相反，高风险 APOL1 基因型的受者在移植后 5 年的移植物存活率没有差异。因此，我们可以得出结论，APOL1 基因型不会增加肾移植后移植物丢失的风险，携带 2 个 APOL1 风险等位基因不应成为移植的障碍。
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