Toledano Adolfo, Borromeo Susana, Luna Guillermo, Molina Elena, Solana Ana Beatriz, García-Polo Pablo, Hernández Juan Antonio, Álvarez-linera Juan
Consulta de Olfato, Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
Acta Otorrinolaringol Esp. 2012 Jul-Aug;63(4):280-5. doi: 10.1016/j.otorri.2012.01.010. Epub 2012 Apr 7.
To show the results of a device that generates automated olfactory stimuli suitable for functional magnetic resonance imaging (fMRI) experiments.
Ten normal volunteers, 5 women and 5 men, were studied. The system allows the programming of several sequences, providing the capability to synchronise the onset of odour presentation with acquisition by a trigger signal of the MRI scanner. The olfactometer is a device that allows selection of the odour, the event paradigm, the time of stimuli and the odour concentration. The paradigm used during fMRI scanning consisted of 15-s blocks. The odorant event took 2s with butanol, mint and coffee.
We observed olfactory activity in the olfactory bulb, entorhinal cortex (4%), amygdala (2.5%) and temporo-parietal cortex, especially in the areas related to emotional integration.
The device has demonstrated its effectiveness in stimulating olfactory areas and its capacity to adapt to fMRI equipment.
展示一种能产生适用于功能磁共振成像（fMRI）实验的自动嗅觉刺激的设备的结果。
对10名正常志愿者进行研究，其中5名女性和5名男性。该系统允许对多个序列进行编程，具备通过MRI扫描仪的触发信号将气味呈现的开始与采集同步的能力。嗅觉计是一种允许选择气味、事件范式、刺激时间和气味浓度的设备。fMRI扫描期间使用的范式由15秒的时间段组成。丁醇、薄荷和咖啡的气味事件持续2秒。
我们在嗅球、内嗅皮质（4%）、杏仁核（2.5%）和颞顶叶皮质观察到嗅觉活动，尤其是在与情绪整合相关的区域。
该设备已证明其在刺激嗅觉区域方面的有效性及其适应fMRI设备的能力。
