使用功能磁共振成像对嗅觉功能进行客观评估。
Objective assessment of olfactory function using functional magnetic resonance imaging.
作者信息
Toledano Adolfo, Borromeo Susana, Luna Guillermo, Molina Elena, Solana Ana Beatriz, García-Polo Pablo, Hernández Juan Antonio, Álvarez-linera Juan
机构信息
Consulta de Olfato, Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
出版信息
Acta Otorrinolaringol Esp. 2012 Jul-Aug;63(4):280-5. doi: 10.1016/j.otorri.2012.01.010. Epub 2012 Apr 7.
OBJECTIVE
To show the results of a device that generates automated olfactory stimuli suitable for functional magnetic resonance imaging (fMRI) experiments.
MATERIAL AND METHODS
Ten normal volunteers, 5 women and 5 men, were studied. The system allows the programming of several sequences, providing the capability to synchronise the onset of odour presentation with acquisition by a trigger signal of the MRI scanner. The olfactometer is a device that allows selection of the odour, the event paradigm, the time of stimuli and the odour concentration. The paradigm used during fMRI scanning consisted of 15-s blocks. The odorant event took 2s with butanol, mint and coffee.
RESULTS
We observed olfactory activity in the olfactory bulb, entorhinal cortex (4%), amygdala (2.5%) and temporo-parietal cortex, especially in the areas related to emotional integration.
CONCLUSIONS
The device has demonstrated its effectiveness in stimulating olfactory areas and its capacity to adapt to fMRI equipment.
目的
展示一种能产生适用于功能磁共振成像（fMRI）实验的自动嗅觉刺激的设备的结果。
材料与方法
对10名正常志愿者进行研究，其中5名女性和5名男性。该系统允许对多个序列进行编程，具备通过MRI扫描仪的触发信号将气味呈现的开始与采集同步的能力。嗅觉计是一种允许选择气味、事件范式、刺激时间和气味浓度的设备。fMRI扫描期间使用的范式由15秒的时间段组成。丁醇、薄荷和咖啡的气味事件持续2秒。
结果
我们在嗅球、内嗅皮质（4%）、杏仁核（2.5%）和颞顶叶皮质观察到嗅觉活动，尤其是在与情绪整合相关的区域。
结论
该设备已证明其在刺激嗅觉区域方面的有效性及其适应fMRI设备的能力。
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