Department of Pharmaceutics, The University of Mississippi, Oxford, Mississippi 38677, USA.
J Pharm Sci. 2012 Jul;101(7):2392-7. doi: 10.1002/jps.23139. Epub 2012 Apr 4.
The main objective of the present study was to investigate the plausibility of iontophoretic delivery of drugs to the nail matrix via proximal nail fold. The in vitro drug transport studies were performed in Franz diffusion cells across folded epidermis, which is used as a model for the proximal nail fold. The amount of drug transported into the receiver compartment following iontophoresis for 3 h at 0.5 mA/cm(2) was 150-fold higher than the control (0.008 ± 0.002 μg/cm(2)). The amount of drug present in the skin after iontophoresis (0.45 ± 0.12 μg/mg) was approximately fivefold higher as compared with that of the control (0.08 ± 0.01 μg/mg). Iontophoresis of terbinafine across the proximal nail fold was assessed using excised cadaver toe model as well. A custom-designed foam-pad-type patch system was used for iontophoresis in cadaver toes. The amount of the drug delivered into the nail matrix following iontophoresis for 3 h was significantly higher than the minimum inhibition concentration of terbinafine. However, on the contrary, passive delivery for about 24 h did not result in any detectable drug levels in the nail matrix. Iontophoresis across the proximal nail fold could be developed as a potential method to target drugs to nail matrix.
本研究的主要目的是研究经近端甲褶离子导入药物至甲母质的可能性。经Franz 扩散池在折叠的表皮（用作近端甲褶模型）上进行体外药物转运研究。在 0.5 mA/cm(2) 下进行 3 小时离子导入后，进入接收器隔室的药物量比对照（0.008 ± 0.002 μg/cm(2)）高 150 倍。离子导入后（0.45 ± 0.12 μg/mg）皮肤中存在的药物量比对照（0.08 ± 0.01 μg/mg）高约五倍。同样使用离体尸体脚趾模型评估了特比萘芬经近端甲褶的离子导入情况。为了在尸体脚趾上进行离子导入，使用了定制的泡沫垫型贴片系统。离子导入 3 小时后，进入甲母质的药物量明显高于特比萘芬的最低抑菌浓度。然而，相反，大约 24 小时的被动给药并未导致甲母质中有任何可检测到的药物水平。经近端甲褶离子导入可以开发为将药物靶向至甲母质的潜在方法。
