Baswan Sudhir, Kasting Gerald B, Li S Kevin, Wickett Randy, Adams Brian, Eurich Sean, Schamper Ryan
James L. Winkle College of Pharmacy, The University of Cincinnati Academic Health Center, Cincinnati, OH, USA.
Amway Corporation, Ada, MI, USA.
Mycoses. 2017 May;60(5):284-295. doi: 10.1111/myc.12592. Epub 2017 Jan 18.
The topical treatment of nail fungal infections has been a focal point of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. Although the current focus remains on exploring the ways of enhancing permeation through the formidable nail barrier, the understanding of the nail microstructure and composition is far from complete. This article reviews our current understanding of the nail microstructure, composition and diseases. A few of the parameters affecting the nail permeability and potential causes of the recurrence of fungal nail infection are also discussed.
在过去几十年里，指甲真菌感染的局部治疗一直是指甲研究的焦点，因为它为传统口服疗法提供了一种更安全、更有针对性的替代方案。尽管目前的重点仍然是探索增强药物透过坚硬指甲屏障的渗透方式，但对指甲微观结构和组成的了解还远远不够完善。本文综述了我们目前对指甲微观结构、组成和疾病的认识。还讨论了一些影响指甲渗透性的参数以及指甲真菌感染复发的潜在原因。
