Department of Chemistry, Bharathiar University, Coimbatore 641 046, India.
Metallomics. 2012 May;4(5):498-511. doi: 10.1039/c2mt00004k. Epub 2012 Apr 10.
Two new copper(I) hydrazone complexes have been synthesised from bivalent copper precursor [CuCl(2)(PPh(3))(2)] and ferrocene containing bidentate hydrazone ligands HL(1) (1) or HL(2) (2). Based on the elemental analyses and spectroscopic data, the complexes are best formulated as [CuL(1)(PPh(3))(2)] (3) and [CuL(2)(PPh(3))(2)] (4) of the monovalent copper ion. Solid state structures of ligand 2 and its corresponding complex 4 were also determined. The DNA/albumin interactions of all the synthesised compounds were investigated using absorption, emission and synchronous fluorescence studies. Further, antioxidant properties of all the compounds have also been checked against ABTS, O(2)(-) and OH radicals. Additionally, the in vitro cytotoxic activity of compounds 1-4 was assessed using tumour (HeLa, A431) and non-tumour (NIH 3T3) cell lines.
两种新型铜（I）腙配合物是由二价铜前体[CuCl(2)(PPh(3))(2)]和二齿腙配体 HL(1) (1) 或 HL(2) (2) 合成的。根据元素分析和光谱数据，这些配合物最好表示为单价铜离子的[CuL(1)(PPh(3))(2)] (3) 和 [CuL(2)(PPh(3))(2)] (4)。配体 2 及其相应配合物 4 的固态结构也已确定。使用吸收、发射和同步荧光研究研究了所有合成化合物与 DNA/白蛋白的相互作用。此外，还针对 ABTS、O(2)(-) 和 OH 自由基检查了所有化合物的抗氧化性能。此外，还使用肿瘤（HeLa、A431）和非肿瘤（NIH 3T3）细胞系评估了化合物 1-4 的体外细胞毒性活性。
