S-腺苷高半胱氨酸的6'-氧类似物。
6'-Oxa Analogs of S-Adenosylhomocysteine.
作者信息
Li Weikuan, Ye Wei, Schneller Stewart W
机构信息
Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849-5312.
出版信息
Tetrahedron. 2012 Jan 7;68(1):65-71. doi: 10.1016/j.tet.2011.10.063.
S-Adenosylmethionine (AdoMet) is a ubiquitous cofactor in biomethylations and, in that role, becomes S-adenosylhomocysteine (AdoHcy), which serves as a biofeedback inhibitor of the methylation process. In seeking to avail unexplored structural variations of AdoHcy for biological studies, its 6'-oxa analog and two corresponding carbocyclic nucleosides (based on aristeromycin and neplanocin) have been prepared via common convergent syntheses.
S-腺苷甲硫氨酸（AdoMet）是生物甲基化过程中普遍存在的一种辅助因子，在此过程中它会转变为S-腺苷同型半胱氨酸（AdoHcy），而AdoHcy作为甲基化过程的生物反馈抑制剂。为了探索AdoHcy尚未被研究的结构变异以用于生物学研究，通过共同的汇聚合成法制备了其6'-氧杂类似物和两种相应的碳环核苷（基于阿糖腺苷和奈拉滨）。
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