De Clercq E
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):625-34. doi: 10.1080/07328319808005205.
Various carbocyclic analogues of adenosine, including aristeromycin (carbocyclic adenosine), carbocyclic 3-deazaadenosine, neplanocin A, 3-deazaneplanocin A, the 5'-nor derivatives of aristeromycin, carbocylic 3-deazaadenosine, neplanocin A and 3-deazaneplanocin A, and the 2-halo (i.e., 2-fluoro) and 6'-R-alkyl (i.e., 6'-R-methyl) derivatives of neplanocin A have been recognized as potent inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase. This enzyme plays a key role in methylation reactions depending on S-adenosylmethionine (AdoMet) as methyl donor. AdoHcy hydrolase inhibitors have been shown to exert broad-spectrum antiviral activity against pox-, paramyxo-, rhabdo-, filo-, bunya-, arena-, and reoviruses. They also interfere with the replication of human immunodeficiency virus through inhibition of the Tat transactivation process.
多种腺苷的碳环类似物，包括阿糖腺苷（碳环腺苷）、碳环3-脱氮腺苷、奈拉滨、3-脱氮奈拉滨、阿糖腺苷的5'-去甲衍生物、碳环3-脱氮腺苷、奈拉滨和3-脱氮奈拉滨，以及奈拉滨的2-卤代（即2-氟）和6'-R-烷基（即6'-R-甲基）衍生物，已被公认为是S-腺苷同型半胱氨酸（AdoHcy）水解酶的有效抑制剂。该酶在以S-腺苷甲硫氨酸（AdoMet）作为甲基供体的甲基化反应中起关键作用。已表明AdoHcy水解酶抑制剂对痘病毒、副粘病毒、弹状病毒、丝状病毒、布尼亚病毒、沙粒病毒和呼肠孤病毒具有广谱抗病毒活性。它们还通过抑制Tat反式激活过程来干扰人类免疫缺陷病毒的复制。
