Department of Radiation Oncology, European Georges-Pompidou Hospital, Paris Descartes University, Paris, France.
Cancer Invest. 2012 May;30(4):323-30. doi: 10.3109/07357907.2012.657818. Epub 2012 Apr 10.
A comparative, nonrandomized, multicenter, and prospective analysis were performed between April 2004 and June 2008 in 20 French centers in order to compare clinical aspects of respiratory-gated conformal radiotherapy (RGRT) during breast cancer irradiation versus conventional conformal radiotherapy. The final results based on 233 evaluable patients at 48 months confirm the feasibility and good reproducibility of the RGRT systems. The main results demonstrated a marked reduction of dosimetric parameters predictive of lungs and cardiac toxicities in the RGRT group; especially the dose delivered to the heart during irradiation of the left breast; mostly observed with deep inspiration breath-hold techniques.
2004 年 4 月至 2008 年 6 月期间，在法国 20 个中心进行了一项比较、非随机、多中心、前瞻性分析，旨在比较乳腺癌放射治疗中呼吸门控适形放射治疗（RGRT）与常规适形放射治疗的临床方面。基于 48 个月时 233 例可评估患者的最终结果证实了 RGRT 系统的可行性和良好的可重复性。主要结果表明，RGRT 组的预测肺和心脏毒性的剂量学参数显著降低；特别是在左侧乳房照射时心脏所接受的剂量；这主要是通过深吸气屏气技术观察到的。
