Ehlert Nina, Hess John, Hager Alfred
Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Congenit Heart Dis. 2012 Sep-Oct;7(5):448-54. doi: 10.1111/j.1747-0803.2012.00645.x. Epub 2012 Apr 10.
In cross-sectional studies, self-reported health status and quality of life have only poorly correlated with objective exercise capacity in patients with congenital heart disease (CHD). We tested the hypothesis whether longitudinal changes in exercise ability are related to changes in self-reported quality of life.
One hundred eighty-two patients (79 female, 103 male, age 14-70 years) with various congenital heart defects were investigated twice. Every time, they completed the SF-36 quality of life survey and performed a symptom-limited cardiopulmonary exercise test. Between the two tests, 32 patients had open heart surgery, 10 had a catheter intervention, 48 patients had a medication change, and 92 had no changes in their management for at least 6 months.
Patients were classified into three groups. Peak oxygen uptake increased by more than 10% in 43 patients; in 84, patients it did not change substantially (±10%); and in 55 patients, it declined by more than 10%. Comparing the three groups, the changes in any of the life quality scales did not differ significantly. Even in self-reported physical functioning, we could not find any differences (Kruskal-Wallis test, P= .563).
In patients with CHD, there was no detectable relation of changes in exercise capacity and changes in self-reported health status or quality of life.
在横断面研究中，先天性心脏病（CHD）患者自我报告的健康状况和生活质量与客观运动能力之间的相关性较差。我们检验了运动能力的纵向变化是否与自我报告的生活质量变化相关的假设。
对182例患有各种先天性心脏缺陷的患者（79例女性，103例男性，年龄14 - 70岁）进行了两次调查。每次，他们都完成了SF - 36生活质量调查问卷，并进行了症状限制心肺运动试验。在两次测试之间，32例患者接受了心脏直视手术，10例接受了导管介入治疗，48例患者改变了药物治疗，92例患者至少6个月内治疗方案未改变。
患者被分为三组。43例患者的峰值摄氧量增加超过10%；84例患者变化不大（±10%）；55例患者下降超过10%。比较三组，任何生活质量量表的变化均无显著差异。即使在自我报告的身体功能方面，我们也未发现任何差异（Kruskal - Wallis检验，P = 0.563）。
在CHD患者中，未发现运动能力变化与自我报告的健康状况或生活质量变化之间存在可检测到的关系。
