The Generation R Study Group, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
Psychol Med. 2013 Jan;43(1):13-25. doi: 10.1017/S0033291712000657. Epub 2012 Apr 11.
It is unclear how the course of maternal depressive symptoms affects child development. We modelled trajectories of maternal depressive symptoms from mid-pregnancy to 3 years after childbirth to better determine their associations with child problem behaviour.
Mother-child dyads (n = 4167) participated in a population-based prospective cohort in The Netherlands. Depressive symptoms were assessed with the Brief Symptom Inventory during pregnancy and at 2, 6 and 36 months postnatally. When children were 3 years old, problem behaviour was assessed with the Child Behaviour Checklist completed by each parent. A group-based modelling technique was used to model trajectories of maternal depressive symptoms and to examine their association with child problem behaviour. The added value of trajectory modelling was determined with successive linear regressions.
We identified four trajectories of maternal depressive symptoms; 'no' (34%), 'low' (54%), 'moderate' (11%) and 'high' (1.5%). Child problem behaviour varied as a function of maternal trajectory membership. Whether rated by mother or father, children of mothers assigned to higher trajectories had significantly more problem behaviours than children of mothers assigned to lower trajectories. The model including trajectories had additive predictive value over a model relying only on a summed repeated measure of severity and a predefined chronicity variable.
Depending on their course, maternal depressive symptoms have different effects on child problem behaviour. More information is gained by studying trajectories of symptoms, than only predefined measures of severity and chronicity. Moreover, trajectories can help identifying clinically depressed mothers who are possible candidates for early interventions.
目前尚不清楚产妇抑郁症状的发展过程如何影响儿童发育。我们对妊娠中期至产后 3 年的产妇抑郁症状轨迹进行建模,以更好地确定其与儿童问题行为的关系。
来自荷兰的一个基于人群的前瞻性队列研究纳入了母婴对子(n=4167)。在妊娠期间和产后 2、6 和 36 个月使用 Brief Symptom Inventory 评估抑郁症状。当孩子 3 岁时,由每位父母使用 Child Behaviour Checklist 评估问题行为。采用基于群组的建模技术来对产妇抑郁症状轨迹进行建模,并检验其与儿童问题行为的关系。采用逐步线性回归来确定轨迹建模的附加价值。
我们确定了产妇抑郁症状的 4 种轨迹:“无”(34%)、“低”(54%)、“中”(11%)和“高”(1.5%)。儿童问题行为随产妇轨迹成员的不同而变化。无论由母亲还是父亲评定,被分配到较高轨迹的母亲的孩子比被分配到较低轨迹的母亲的孩子表现出更多的问题行为。与仅依赖于重复测量严重程度的总和和预定义的慢性变量的模型相比,纳入轨迹的模型具有附加的预测价值。
根据其发展过程,产妇抑郁症状对儿童问题行为有不同的影响。通过研究症状轨迹而不是仅使用严重程度和慢性的预定义测量,可以获得更多信息。此外,轨迹可以帮助识别可能是早期干预候选者的临床抑郁母亲。