Fraser Clare L, Biousse Valerie, Newman Nancy J
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Arch Neurol. 2012 Aug;69(8):1067-70. doi: 10.1001/archneurol.2012.144.
To describe the clinical course of an unusually severe case of minocycline-induced intracranial hypertension.
Case study.
Academic medical center.
Twelve-year-old girl with a fulminant course of intracranial hypertension.
Magnetic resonance imaging and venography of the brain, lumbar puncture, and optic nerve sheath fenestration.
Although the patient ceased minocycline treatment, there was ongoing and rapid worsening of symptoms and vision loss. Lumbar puncture, which normally acts as a temporizing measure to preserve vision, failed to prevent, and may even have precipitated, further deterioration in vision, necessitating surgical intervention with optic nerve sheath fenestration.
Minocycline can cause a fulminant syndrome of elevated intracranial pressure, with severe vision loss, even after the medication has been discontinued.
描述一例米诺环素诱发的颅内高压异常严重病例的临床病程。
病例研究。
学术医疗中心。
一名12岁女童，颅内高压病情发展迅猛。
脑部磁共振成像和静脉造影、腰椎穿刺及视神经鞘开窗术。
尽管患者停止了米诺环素治疗，但症状仍持续且迅速恶化，视力丧失。腰椎穿刺通常作为保护视力的临时措施，却未能预防甚至可能促使视力进一步恶化，因此需要进行视神经鞘开窗术这一外科干预。
即使停药后，米诺环素仍可导致颅内压急剧升高的综合征，并伴有严重视力丧失。
