Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Exp Biol Med (Maywood). 2012 Apr;237(4):343-51. doi: 10.1258/ebm.2011.011359. Epub 2012 Apr 4.
Neural transplantation as a therapeutic strategy in neurodegenerative disorders offers to replace cells lost during the disease process, with the potential to reconstruct dysfunctional circuitry, thus alleviating associated disease symptoms. The focal loss of striatal cells, specifically medium-sized spiny neurons (MSN) in Huntington's disease (HD), makes transplantation a therapeutic option. Here, we review the progress made in generating striatal MSN phenotypes for transplantation in HD. We discuss the use of primary fetal tissue as a donor source in both preclinical and clinical studies and assess the options for renewable cell sources. We evaluate progress in directing the differentiation of renewable cells towards a striatal MSN phenotype for HD.
神经移植作为神经退行性疾病的一种治疗策略，旨在用在疾病过程中丢失的细胞进行替换，具有重建功能障碍回路的潜力，从而缓解相关疾病症状。亨廷顿病（HD）中纹状体细胞，特别是中型棘神经元（MSN）的局灶性丧失，使得移植成为一种治疗选择。在这里，我们回顾了在产生用于 HD 移植的纹状体 MSN 表型方面所取得的进展。我们讨论了使用原代胎儿组织作为供体来源在临床前和临床研究中的应用，并评估了可再生细胞来源的选择。我们评估了将可再生细胞向 HD 中的纹状体 MSN 表型定向分化的进展。
