可溶性B7-H4在恶性胸腔积液中的诊断价值
[Diagnostic value of soluble B7-H4 in malignant pleural effusion].
作者信息
Xu Chun-hua, Yu Li-ke
机构信息
Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2012 Jan 10;92(2):117-8.
OBJECTIVE
To explore the diagnostic value of soluble B7-H4 (sB7-H4) in tuberculous pleural effusion and malignant pleural effusion.
METHODS
A total of 98 patients of pleural effusion treated in Nanjing Chest Hospital from January 2007 to December 2009 were enrolled. The etiologies were tuberculous (n = 48) and malignant (n = 50). The levels of sB7-H4 in pleural effusion were detected by sandwich enzyme linked immunosorbent assay. The rational clinical diagnostic value was established by receiver operating characteristic (ROC) curves.
RESULTS
The level of sB7-H4 in malignant pleural effusion was significant higher than that in tuberculous effusion ((65.7 ± 5.8) vs (28.6 ± 8.7) µg/L, P < 0.05). The cut-off value of sB7-H4 was 36.5 µg/L for malignant pleural effusion. And the rates of sensitivity, specificity and accuracy were 92.0%, 83.3% and 87.8% respectively.
CONCLUSION
The level of sB7-H4 may be used as a valuable parameter in the differentiation of tuberculous from malignant effusion.
目的
探讨可溶性B7-H4（sB7-H4）在结核性胸腔积液和恶性胸腔积液中的诊断价值。
方法
选取2007年1月至2009年12月在南京市胸科医院治疗的98例胸腔积液患者。病因分为结核性（n = 48）和恶性（n = 50）。采用夹心酶联免疫吸附测定法检测胸腔积液中sB7-H4的水平。通过绘制受试者工作特征（ROC）曲线确定其合理的临床诊断价值。
结果
恶性胸腔积液中sB7-H4水平显著高于结核性胸腔积液（（65.7 ± 5.8）对（28.6 ± 8.7）μg/L，P < 0.05）。恶性胸腔积液中sB7-H4的截断值为36.5 μg/L。其敏感性、特异性和准确性分别为92.0%、83.3%和87.8%。
结论
sB7-H4水平可作为鉴别结核性与恶性胸腔积液的有价值参数。
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