Laboratory of Veterinary Parasitic Diseases, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
Exp Parasitol. 2012 Jun;131(2):190-4. doi: 10.1016/j.exppara.2012.03.023. Epub 2012 Apr 3.
Paraoxonase-1 (PON1) is an HDL-associated enzyme with anti-atherogenic properties. Reduced PON1 activity has previously been observed in Nippostrongylus brasiliensis-infected rats. However, the effect of chronic zoonotic nematode infections on serum PON1 activity has not yet been studied. Therefore, we evaluated the effect of Trichinella spiralis infection on serum PON1 activity, the lipid profile, and oxidative stress in rats. There were significant reductions in serum PON1 activities (Day 2-Week 7 post-infection) in rats infected with T. spiralis, and these reductions were associated with significant increases in the serum levels of triglyceride and LDL/VLDL, as well as a significant reduction in the level of HDL. Moreover, T. spiralis infection was associated with a status of oxidative stress indicated by increased concentrations of superoxide dismutase and malondialdehyde. Given the zoonotic prevalence of T. spiralis and the cardioprotective role of PON1, further mechanistic research in this area is warranted.
对氧磷酶 1（PON1）是一种具有抗动脉粥样硬化特性的高密度脂蛋白相关酶。先前在感染旋毛虫的大鼠中观察到 PON1 活性降低。然而，慢性人畜共患线虫感染对血清 PON1 活性的影响尚未得到研究。因此，我们评估了旋毛虫感染对大鼠血清 PON1 活性、血脂谱和氧化应激的影响。感染旋毛虫的大鼠血清 PON1 活性显著降低（感染后第 2 天-第 7 周），这些降低与血清甘油三酯和 LDL/VLDL 水平的显著升高以及 HDL 水平的显著降低有关。此外，旋毛虫感染与超氧化物歧化酶和丙二醛浓度增加表明的氧化应激状态有关。鉴于旋毛虫的人畜共患流行和 PON1 的心脏保护作用，该领域的进一步机制研究是必要的。
