Department of Biology, Indiana University, Bloomington, IN, USA.
Neurosci Lett. 2012 May 16;516(2):193-6. doi: 10.1016/j.neulet.2012.03.079. Epub 2012 Apr 3.
The primate somatosensory system provides an excellent model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for the GluR1 and GluR2/3 AMPA receptor subunits in the cuneate nucleus of adult squirrel monkeys one week after median nerve compression. These data are compared to subunit changes in the area 3b cortex of the same animals. We report differences between control and deprived brainstem implying that deprivation induced changes in subunit expression mirror those reported in the cortex. There are significant increases in GluR1 receptor subunit staining intensity and significant decreases in GluR2/3 receptor subunit staining intensity. This pattern of expression resembles receptor configurations reported in developing sensory systems. Taken together, these results suggest that the brainstem and the cortex initially progress through a phase of developmental recapitulation prior to the onset of NMDA mediated adult somatosensory reorganization.
灵长类动物的躯体感觉系统是研究成年神经可塑性的极佳模型系统。在这里，我们报告了成年松鼠猴正中神经压迫后一周，楔状核内 GluR1 和 GluR2/3 AMPA 受体亚基的免疫组织化学染色数据，并将其与同一动物大脑皮质 3b 区的亚基变化进行了比较。我们报告了对照组和剥夺组之间的脑桥差异，这表明剥夺诱导的亚基表达变化与皮质中报告的变化相似。GluR1 受体亚基染色强度显著增加，GluR2/3 受体亚基染色强度显著降低。这种表达模式类似于发育中的感觉系统中报道的受体结构。总之，这些结果表明，脑桥和大脑皮质在 NMDA 介导的成年躯体感觉重组发生之前，最初经历了一个发育性重演的阶段。
