Department of Experimental Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS Groningen, The Netherlands.
Neurosci Lett. 2012 May 10;516(1):130-4. doi: 10.1016/j.neulet.2012.03.073. Epub 2012 Apr 2.
The brain networks that are involved in flanker incongruity and error processing are also consistently implicated in mental disorders such as obsessive compulsive disorder (OCD) that feature increased "Doubts about Actions" (DaA) scores. In the present study we investigated whether DaA scores, similar to what has been found for its positive correlate, OCD symptom severity scores, predict less interference from incompatible flankers during an Eriksen flanker task. Sixteen healthy right-handed female participants performed the flanker task and event-related potentials to the stimuli were recorded. DaA, but not other trait measures such as concern over mistakes and punishment sensitivity, related to less interference from incompatible flankers on performance and a smaller increase in N2 amplitude on incongruent compared to congruent flanker trials. This seems to point to a strategy or focused attention capacity to minimize flanker interference effects. The present results suggest that specific attentional capacities or strategies that appear to characterize disorders such as OCD, are related to disorder-associated traits in healthy populations as well.
参与侧抑制不和谐和错误处理的大脑网络也与强迫症（OCD）等精神障碍密切相关，这些障碍的特征是“对行动的怀疑”（DaA）评分增加。在本研究中，我们调查了 DaA 评分是否与正相关的 OCD 症状严重程度评分相似，可预测在 Eriksen 侧抑制任务中，来自不兼容侧抑制的干扰减少。16 名健康的右利手女性参与者完成了侧抑制任务，并记录了对刺激的事件相关电位。DaA，但不是其他特质测量，如对错误的关注和惩罚敏感性，与干扰较小的不兼容侧抑制与性能和在不一致的相比，在不和谐的侧抑制试验中 N2 振幅增加较小。这似乎指向一种策略或集中注意力的能力，以最大限度地减少侧抑制干扰效应。目前的结果表明，在健康人群中，与 OCD 等疾病相关的特定注意力能力或策略，也与疾病相关的特征有关。
