对新型β-内酰胺类抗生素耐药的机制及临床意义
Mechanisms and clinical significance of resistance to new beta-lactam antibiotics.
作者信息
Livermore D M, Wood M J
机构信息
Department of Medical Microbiology, London Hospital Medical College.
出版信息
Br J Hosp Med. 1990 Oct;44(4):252-8, 261-3.
PMID:2249100
Abstract
The newer beta-lactam antibiotics, including various ureidopenicillins, second- and third-generation cephalosporins, carbapenems and monobactams, are active against many bacteria that are resistant to older penicillins, such as ampicillin and ticarcillin. Nonetheless, resistance to the newer agents can arise, and in this article the mechanisms whereby it does so are reviewed and their clinical significance is discussed.
摘要
新型β-内酰胺类抗生素，包括各种脲基青霉素、第二代和第三代头孢菌素、碳青霉烯类和单环β-内酰胺类，对许多对老一代青霉素（如氨苄西林和替卡西林）耐药的细菌具有活性。尽管如此，对新型药物的耐药性仍可能出现，本文将对其产生机制进行综述，并讨论其临床意义。
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