Gayral P
Laboratoire de parasitologie, Faculté de pharmacie, Châtenay-Malabry.
Bull Acad Natl Med. 1990 May;174(5):627-32; discussion 632-5.
Amongst several other chemical series, the epoxi and ethylenesulfonamides (which are more stable) have been selected after that we have shown good filaricidal activities on the Filaria Molinema dessetae. This has been confirmed on other models. Good activity was observed with O. gutturosa adult male in vitro, while microfilariae of O. lienalis were insusceptible to the selected compounds. The future of these products was discussed, in the prospect of their development and in relation with their mode of action and the other available pharmacological data.
在其他几个化学系列中，环氧和乙烯磺酰胺（更稳定）是在我们对丝状线虫（Molinema dessetae）显示出良好的杀丝虫活性之后被选出来的。这在其他模型上得到了证实。在体外对牛带绦虫（O. gutturosa）成年雄性观察到良好活性，而绵羊带绦虫（O. lienalis）的微丝蚴对所选化合物不敏感。讨论了这些产品的未来，包括其开发前景以及与作用方式和其他现有药理学数据的关系。
