万古霉素耐药屎肠球菌对替加环素、达托霉素和利奈唑胺敏感性的趋势及分离株的分子流行病学：来自 2006 年至 2010 年台湾替加环素体外监测（TIST）研究的结果。
Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010.
机构信息
Section of Infectious Diseases, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
出版信息
Antimicrob Agents Chemother. 2012 Jun;56(6):3402-5. doi: 10.1128/AAC.00533-12. Epub 2012 Apr 9.
Abstract
Among the 219 vancomycin-resistant Enterococcus faecium isolates collected in 20 Taiwanese hospitals from 2006 to 2010, all were susceptible to linezolid and daptomycin, and 98.6% were susceptible to tigecycline. There was a shift toward higher tigecycline MIC values (MIC(90)s) from 2006-2007 (0.06 μg/ml) to 2008-2010 (0.12 μg/ml). The MIC(90)s of daptomycin and linezolid remained stationary. Although pulsotypes among the isolates from the 20 hospitals varied, intrahospital spreading of several clones was identified in 13 hospitals.
摘要
在 2006 年至 2010 年间，从台湾 20 家医院采集的 219 株万古霉素耐药粪肠球菌中，所有菌株均对利奈唑胺和达托霉素敏感，98.6%对替加环素敏感。替加环素 MIC 值（MIC90）从 2006-2007 年（0.06μg/ml）升高到 2008-2010 年（0.12μg/ml）。达托霉素和利奈唑胺的 MIC90 保持稳定。虽然 20 家医院分离株的脉冲场凝胶电泳图谱不同，但在 13 家医院中发现了几个克隆株在院内传播。
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