Huang Changbao, Zhang Xigang, Jiang Yun, Li Guang, Wang Haochun, Tang Xueping, Wang Qunli
Department of Emergency, 307 Hospital of Chinese PLA, Beijing, China.
Toxicol Ind Health. 2013 Sep;29(8):722-7. doi: 10.1177/0748233712442712. Epub 2012 Apr 4.
Paraquat (PQ) is a potent toxicant for humans, and poisoning with PQ is associated with high mortality. Patients with severe PQ-induced poisoning may die of multiple organ failure involving the circulatory and respiratory systems. Death resulting from epilepsy-like convulsions, which are infrequently noted reported with PQ poisoning, is observed clinically with this condition. This study presents the clinical data of five patients with severe PQ-induced poisoning who died of epilepsy-like convulsions, and related publications were reviewed in order to investigate the pathogenesis, clinical manifestations, and prognosis of these convulsions. Our results may help prevent this event and improve the success of treatment.
百草枯（PQ）是一种对人类有剧毒的毒物，PQ中毒与高死亡率相关。重度PQ中毒患者可能死于涉及循环系统和呼吸系统的多器官功能衰竭。临床上观察到，PQ中毒很少出现癫痫样惊厥导致的死亡，但这种情况在此类病症中确实存在。本研究呈现了5例因癫痫样惊厥死亡的重度PQ中毒患者的临床资料，并对相关出版物进行了综述，以探究这些惊厥的发病机制、临床表现和预后。我们的研究结果可能有助于预防此类事件并提高治疗成功率。
