Postgraduate Course Stress Management and Health Promotion, Athens Kapodistrian National University Medical School, and Department of Neurology, Aeginition Hospital, Athens, Greece.
Arch Clin Neuropsychol. 2012 Jun;27(4):406-16. doi: 10.1093/arclin/acs039. Epub 2012 Apr 3.
There is a well-established adverse reciprocal relationship between stress and multiple sclerosis (MS). However, stress management in these patients has been parsimoniously studied. In this parallel randomized controlled trial, relapsing-remitting MS patients were randomly assigned to undergo either an 8-week stress management program (n=31; relaxation breathing and progressive muscle relaxation, twice a day) or not (n=30). Self-reported validated measures were used to evaluate perceived stress, health locus of control, anxiety, and depression. Daily diaries of MS symptoms were also kept by patients. In patients in the intervention group, perceived stress and symptoms of depression were significantly decreased after 8 weeks of relaxation. Repeated measures analyses showed significant group-by-time interactions for both the number of weekly symptoms and the mean intensity per symptom. No other significant change was reported. We deem that our results should encourage future studies that will incorporate more objective clinical and laboratory outcomes.
压力与多发性硬化症（MS）之间存在着明确的负相关关系。然而，针对这些患者的压力管理研究却很少。在这项平行随机对照试验中，复发缓解型 MS 患者被随机分为两组，分别接受为期 8 周的压力管理方案（n=31；每天两次进行放松呼吸和渐进性肌肉松弛）或不接受该方案（n=30）。使用经过验证的自我报告量表评估感知压力、健康控制源、焦虑和抑郁。患者还每天记录 MS 症状日记。在干预组患者中，经过 8 周的放松后，感知压力和抑郁症状显著减轻。重复测量分析显示，每周症状数量和每个症状的平均强度均存在显著的组间时间交互作用。没有报告其他显著变化。我们认为，我们的研究结果应该鼓励未来的研究纳入更多客观的临床和实验室结局。
