Agland Susan, Lydon Amanda, Shaw Sally, Lea Rodney, Mortimer-Jones Sheila, Lechner-Scott Jeannette
Department of Neurology, John Hunter Hospital, Australia.
Department of Neurology, Eastern Health, Australia.
Mult Scler J Exp Transl Clin. 2018 Nov 26;4(4):2055217318813179. doi: 10.1177/2055217318813179. eCollection 2018 Oct-Dec.
Despite evidence of perceived stress as a risk factor for multiple sclerosis activity, the evidence for managing stress is limited.Objective To evaluate a stress management programme on perceived stress and quality of life, over 6 months.
One hundred people with multiple sclerosis were randomly assigned to either a stress management programme of mindfulness, meditation and progressive muscle relaxation, or wait list. Perceived stress and quality of life were assessed at three intervals across 6 months. Salivary cortisol levels were assessed at two intervals: baseline and first follow-up.
The stress management programme did not significantly reduce perceived stress, when comparing mean scores. Secondary analysis using median scores found a significant improvement for quality of life, favouring the intervention group.
Stress management had no significant effect on the primary outcome of perceived stress but did improve quality of life in a secondary analysis of median scores.
尽管有证据表明感知压力是多发性硬化症活动的一个风险因素，但应对压力的证据有限。目的是评估一项为期6个月的压力管理计划对感知压力和生活质量的影响。
100名多发性硬化症患者被随机分配到正念、冥想和渐进性肌肉松弛的压力管理计划组或等待名单组。在6个月内分三个时间点评估感知压力和生活质量。在两个时间点评估唾液皮质醇水平：基线和首次随访。
比较平均得分时，压力管理计划并未显著降低感知压力。使用中位数得分的二次分析发现，生活质量有显著改善，干预组更优。
压力管理对感知压力这一主要结果没有显著影响，但在中位数得分的二次分析中确实改善了生活质量。
