压力管理计划能否减轻被诊断患有多发性硬化症的患者的压力并改善其生活质量？
Can a stress management programme reduce stress and improve quality of life in people diagnosed with multiple sclerosis?
作者信息
Agland Susan, Lydon Amanda, Shaw Sally, Lea Rodney, Mortimer-Jones Sheila, Lechner-Scott Jeannette
机构信息
Department of Neurology, John Hunter Hospital, Australia.
Department of Neurology, Eastern Health, Australia.
出版信息
Mult Scler J Exp Transl Clin. 2018 Nov 26;4(4):2055217318813179. doi: 10.1177/2055217318813179. eCollection 2018 Oct-Dec.
BACKGROUND
Despite evidence of perceived stress as a risk factor for multiple sclerosis activity, the evidence for managing stress is limited.Objective To evaluate a stress management programme on perceived stress and quality of life, over 6 months.
METHODS
One hundred people with multiple sclerosis were randomly assigned to either a stress management programme of mindfulness, meditation and progressive muscle relaxation, or wait list. Perceived stress and quality of life were assessed at three intervals across 6 months. Salivary cortisol levels were assessed at two intervals: baseline and first follow-up.
RESULTS
The stress management programme did not significantly reduce perceived stress, when comparing mean scores. Secondary analysis using median scores found a significant improvement for quality of life, favouring the intervention group.
CONCLUSION
Stress management had no significant effect on the primary outcome of perceived stress but did improve quality of life in a secondary analysis of median scores.
背景
尽管有证据表明感知压力是多发性硬化症活动的一个风险因素，但应对压力的证据有限。目的是评估一项为期6个月的压力管理计划对感知压力和生活质量的影响。
方法
100名多发性硬化症患者被随机分配到正念、冥想和渐进性肌肉松弛的压力管理计划组或等待名单组。在6个月内分三个时间点评估感知压力和生活质量。在两个时间点评估唾液皮质醇水平：基线和首次随访。
结果
比较平均得分时，压力管理计划并未显著降低感知压力。使用中位数得分的二次分析发现，生活质量有显著改善，干预组更优。
结论
压力管理对感知压力这一主要结果没有显著影响，但在中位数得分的二次分析中确实改善了生活质量。
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