Falk S, Stutte H J
Department of Pathology, University of Frankfurt, Federal Republic of Germany.
Cancer. 1990 Dec 15;66(12):2612-9. doi: 10.1002/1097-0142(19901215)66:12<2612::aid-cncr2820661225>3.0.co;2-q.
Seventeen cases of primary malignant lymphoma of the spleen (PMLS) were identified among 500 splenectomy specimens showing involvement by Hodgkin's disease or non-Hodgkin's lymphoma. All PMLS represented non-Hodgkin's lymphoma and most of them were of B-cell origin. In two cases PMLS were associated with hamartomas of the spleen (splenomas). Histologic and immunohistochemical studies did not reveal any differences between PMLS and disseminated malignant lymphomas with splenic involvement with regard to morphologic features, immunophenotype, host cell infiltrates, or proliferation activity. The reasons for the infrequent occurrence of primary lymphomas in the spleen may not be sought in a special immunophenotype of PMLS, a vigorous host response in the spleen, or in a lower proliferation activity of splenic lymphomas.
在500例显示有霍奇金病或非霍奇金淋巴瘤累及的脾切除标本中，确诊了17例原发性脾恶性淋巴瘤（PMLS）。所有PMLS均为非霍奇金淋巴瘤，且大多数起源于B细胞。2例PMLS与脾错构瘤（脾瘤）相关。组织学和免疫组化研究未发现PMLS与有脾受累的播散性恶性淋巴瘤在形态学特征、免疫表型、宿主细胞浸润或增殖活性方面存在任何差异。脾脏原发性淋巴瘤发生率低的原因可能不在于PMLS的特殊免疫表型、脾脏中强烈的宿主反应或脾淋巴瘤较低的增殖活性。
