Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Angiology. 2013 Feb;64(2):157-60. doi: 10.1177/0003319712438956. Epub 2012 Apr 9.
Procoagulant and prothrombotic states in patients with chronic atrial fibrillation (AF) are higher than those in patients with normal sinus rhythm. We assessed and compared serum γ-glutamyltranferase (GGT) activity in elderly patients with nonvalvular AF and control participants with normal sinus rhythm. Consecutive patients (n = 81) with nonvalvular chronic AF and 210 age- and gender-matched control participants with normal sinus rhythm were retrospectively included in the study from the outpatient cardiology clinic. Presence of coronary artery disease, hypertension, gender, hyperlipidemia, diabetes mellitus, smoking status, glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and ejection fraction were comparable between the 2 groups (P > .05 for all). However, serum γ-GGT activity was significantly higher (P = .003) in patients with AF compared with those without AF. We have shown that serum γ-GGT activity is independently associated with chronic nonvalvular AF.
慢性心房颤动（AF）患者的促凝和血栓形成状态高于窦性心律正常患者。我们评估并比较了老年非瓣膜性 AF 患者和窦性心律正常对照组的血清 γ-谷氨酰转移酶（GGT）活性。从门诊心内科回顾性纳入了 81 例非瓣膜性慢性 AF 连续患者和 210 例年龄和性别匹配的窦性心律正常对照组。两组之间的冠心病、高血压、性别、高脂血症、糖尿病、吸烟状况、血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和射血分数无差异（所有 P 值均>.05）。然而，AF 患者的血清 γ-GGT 活性明显高于无 AF 患者（P =.003）。我们已经表明，血清 γ-GGT 活性与慢性非瓣膜性 AF 独立相关。
