State Key Laboratory of Bioorganic and Natural Products, Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
Angew Chem Int Ed Engl. 2012 May 14;51(20):4968-71. doi: 10.1002/anie.201201395. Epub 2012 Apr 11.
A highly efficient enantioselective total synthesis of the natural antibiotic IKD-8344 is achieved through a convergent route. This route features an otherwise impossible concurrent formation of the THF rings from a linear polyketide precursor through intramolecular O alkylations of mesylates in competition with normally rather facile β elimination and/or α racemization reactions (see scheme, Ms=methanesulfonyl).
通过会聚途径实现了天然抗生素 IKD-8344 的高效对映选择性全合成。该途径的特点是通过线性聚酮前体的分子内 O 烷基化反应（与通常相当容易的β消除和/或α外消旋化反应竞争），否则不可能同时形成 THF 环（见方案，Ms=甲烷磺酰基）。
