抗真菌和抗菌剂枝状葡萄藻素的模型研究及首次合成

Model studies and first synthesis of the antifungal and antibacterial agent cladobotryal.

作者信息

Clive Derrick L J, Huang Xiaojun

机构信息

Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.

出版信息

J Org Chem. 2004 Mar 19;69(6):1872-9. doi: 10.1021/jo030284g.

DOI:10.1021/jo030284g

PMID:15058932

Abstract

The antifungal and antibacterial agent cladobotryal (1) was synthesized by a convergent route from lactone 31 and aldehyde 13, a key step in the elaboration of the pyridinone ring being conversion of a Boc group on nitrogen into a CO(2)SiPr-i(3) group. The simple model compounds 9 and 10, representing the core of cladobotryal and of 5, respectively, were prepared as support studies for making the natural product.

摘要

抗真菌和抗菌剂枝状多孢菌素（1）通过内酯31和醛13的汇聚路线合成，吡啶酮环构建中的关键步骤是将氮上的Boc基团转化为CO(2)SiPr-i(3)基团。分别作为枝状多孢菌素和5的核心的简单模型化合物9和10被制备出来，作为制备天然产物的辅助研究。