Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
Circulation. 2012 May 8;125(18):2212-21. doi: 10.1161/CIRCULATIONAHA.111.065904. Epub 2012 Apr 9.
Because of rapid change in lifestyle risk factors, cardiovascular disease has become the leading cause of death in China. We sought to estimate the national levels of serum lipids and lipoproteins among the Chinese adult population.
We conducted a cross-sectional study in a nationally representative sample of 46 239 adults aged ≥20 years. Fasting serum total, high-density lipoprotein, and low-density lipoprotein cholesterol and triglycerides were measured by standard methods. The age-standardized estimates of total, high-density lipoprotein, and low-density lipoprotein cholesterol and triglycerides were 4.72 (95% confidence interval, 4.70-4.73), 1.30 (1.29-1.30), 2.68 (2.67-2.70), and 1.57 (1.55-1.58) mmol/L, respectively, in the Chinese adult population. In addition, 22.5% (21.8-23.3%) or 220.4 million (212.1-228.8) Chinese adults had borderline high total cholesterol (5.18-6.21 mmol/L), and 9.0% (8.5-9.5%) or 88.1 million (83.4-92.8) had high total cholesterol (≥6.22 mmol/L). The population estimates for borderline high (3.37-4.13 mmol/L), high (4.14-4.91 mmol/L), and very high (≥4.92 mmol/L) low-density lipoprotein cholesterol were 13.9% (13.3-14.5%) or 133.5 million (127.0-140.1), 3.5% (3.3-3.8%) or 33.8 million (31.2-36.5), and 3.0% (2.8-3.3%) or 29.0 million (26.3-31.8) persons, respectively. In addition, 22.3% (21.6-23.1%) or 214.9 million (207.0-222.8) persons had low high-density lipoprotein cholesterol (<1.04 mmol/L). The awareness, treatment, and control of borderline high or high total cholesterol were 11.0%, 5.1%, and 2.8%, respectively, in the Chinese adult population.
Serum total and low-density lipoprotein cholesterol levels were high and increasing in the Chinese population. Without effective intervention, atherosclerotic cardiovascular diseases may soar in the near future in China.
由于生活方式危险因素的快速变化，心血管疾病已成为中国的主要死亡原因。我们试图估计中国成年人群的血清脂质和脂蛋白水平。
我们对一个具有全国代表性的 46239 名≥20 岁成年人进行了一项横断面研究。采用标准方法测定空腹血清总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇及甘油三酯。中国成年人的年龄标准化总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯估计值分别为 4.72（95%置信区间，4.70-4.73）mmol/L、1.30（1.29-1.30）mmol/L、2.68（2.67-2.70）mmol/L和 1.57（1.55-1.58）mmol/L。此外，22.5%（21.8-23.3%）或 220.4 百万（212.1-228.8）中国成年人的总胆固醇边缘升高（5.18-6.21mmol/L），9.0%（8.5-9.5%）或 88.1 百万（83.4-92.8）的成年人总胆固醇升高（≥6.22mmol/L）。边缘升高（3.37-4.13mmol/L）、升高（4.14-4.91mmol/L）和极高（≥4.92mmol/L）低密度脂蛋白胆固醇的人群估计值分别为 13.9%（13.3-14.5%）或 133.5 百万（127.0-140.1）、3.5%（3.3-3.8%）或 33.8 百万（31.2-36.5）和 3.0%（2.8-3.3%）或 29.0 百万（26.3-31.8）。此外，22.3%（21.6-23.1%）或 214.9 百万（207.0-222.8）的成年人存在低高密度脂蛋白胆固醇（<1.04mmol/L）。中国成年人的总胆固醇边缘升高或升高的知晓率、治疗率和控制率分别为 11.0%、5.1%和 2.8%。
中国人群的血清总胆固醇和低密度脂蛋白胆固醇水平较高且呈上升趋势。如果不采取有效干预措施，中国未来可能会出现动脉粥样硬化性心血管疾病的飙升。
