BH3-only proteins in apoptosis at a glance.
作者信息
Happo Lina, Strasser Andreas, Cory Suzanne
机构信息
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.
出版信息
J Cell Sci. 2012 Mar 1;125(Pt 5):1081-7. doi: 10.1242/jcs.090514.
Abstract
摘要
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EMBO J. 2011 Aug 23;30(18):3667-83. doi: 10.1038/emboj.2011.307.
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Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization.瞬时结合激活剂 BH3 结构域到 Bak BH3 结合沟启动 Bak 寡聚化。
J Cell Biol. 2011 Jul 11;194(1):39-48. doi: 10.1083/jcb.201102027. Epub 2011 Jul 4.
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Non-apoptotic role of BID in inflammation and innate immunity.BID 在炎症和天然免疫中的非凋亡作用。
Nature. 2011 Jun 2;474(7349):96-9. doi: 10.1038/nature09982. Epub 2011 May 8.
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Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis.糖皮质激素介导的致癌性微小RNA簇miR-17~92的抑制作用有助于Bim的诱导和细胞凋亡的启动。
Mol Endocrinol. 2011 Mar;25(3):409-20. doi: 10.1210/me.2010-0402. Epub 2011 Jan 14.
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The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.Noxa 在人白血病细胞中的促凋亡功能受激酶 Cdk5 和葡萄糖调节。
Mol Cell. 2010 Dec 10;40(5):823-33. doi: 10.1016/j.molcel.2010.11.035.
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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity.纳维托昔单抗，一种靶向高亲和力的 BCL-2 抑制剂，用于淋巴恶性肿瘤：安全性、药代动力学、药效学和抗肿瘤活性的 1 期剂量递增研究。
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