Department of Ophthalmology, Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada .
Br J Ophthalmol. 2012 Jun;96(6):776-80. doi: 10.1136/bjophthalmol-2011-301263. Epub 2012 Apr 4.
Endophthalmitis remains one of the most damaging and challenging complications following Boston keratoprosthesis type 1 (KPro) surgery. The authors reviewed the literature from 2001 onward to identify cases of endophthalmitis following KPro surgery and present an additional case of endophthalmitis in a patient with Stevens Johnson syndrome. The prevalence of endophthalmitis between 2001 and 2011 was 5.4%. Gram-positive bacteria are the most common agents responsible for endophthalmitis in this patient population while gram-negative bacteria and fungi are emerging pathogens. Risk factors for endophthalmitis include preoperative diagnosis of cicatricial disease and postoperative infectious keratitis, glaucoma drainage device erosion and non-compliance with antibiotic prophylaxis. Additional studies on the prevention and treatment of endophthalmitis are required to improve the overall prognosis of these patients.
眼内炎仍然是波士顿 1 型角膜热成形术后最具破坏性和挑战性的并发症之一。作者回顾了 2001 年以后的文献，以确定 KPro 手术后眼内炎的病例，并介绍了史蒂文斯-约翰逊综合征患者眼内炎的另外一个病例。2001 年至 2011 年期间，眼内炎的患病率为 5.4%。在这一患者人群中，革兰氏阳性菌是引起眼内炎的最常见病原体，而革兰氏阴性菌和真菌则是新兴的病原体。眼内炎的危险因素包括术前诊断为瘢痕性疾病和术后感染性角膜炎、青光眼引流装置侵蚀以及抗生素预防措施不遵守。需要进一步研究眼内炎的预防和治疗方法，以改善这些患者的总体预后。
