Integrated Department of Immunology, University of Colorado School of Medicine, Aurora, CO, USA.
Anticancer Res. 2012 Apr;32(4):1119-36.
Many recent studies suggest the immune system plays a significant role in the pathogenesis of autoimmune diseases, chronic inflammatory diseases, and cancer.
Literature published between 2001 and 2011 was reviewed for risk of cancer development in patients with autoimmune and chronic inflammatory diseases. Mode of risk assessment employed did not limit inclusion of studies. Autoimmune conditions developing after diagnosis of a pre-existing cancer were also considered.
We report a pervasive, largely positive association between 23 autoimmune and inflammatory diseases and subsequent cancer development. We discuss associations for celiac disease, inflammatory bowel disease rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis in detail. We also address the less frequently reported development of some autoimmune conditions within the course of some malignancies, such as vitiligo developing in the course of melanoma.
Evidence demonstrates that chronic inflammation and autoimmunity are associated with the development of malignancy. Additionally, patients with a primary malignancy may develop autoimmune like disease. These relationships imply a need for surveillance of patients on immunomodulatory therapies for potential secondary disease processes.
许多最近的研究表明免疫系统在自身免疫性疾病、慢性炎症性疾病和癌症的发病机制中起着重要作用。
对 2001 年至 2011 年间发表的文献进行了回顾，以评估自身免疫性和慢性炎症性疾病患者癌症发展的风险。所采用的风险评估模式并未限制纳入研究。也考虑了在先前存在的癌症诊断后发生的自身免疫性疾病。
我们报告了 23 种自身免疫性和炎症性疾病与随后癌症发展之间普遍存在的、在很大程度上呈阳性的关联。我们详细讨论了乳糜泻、炎症性肠病、类风湿关节炎、系统性红斑狼疮和多发性硬化症的关联。我们还讨论了一些恶性肿瘤中不太常报道的自身免疫性疾病的发生，例如黑色素瘤过程中出现的白癜风。
证据表明慢性炎症和自身免疫与恶性肿瘤的发展有关。此外，患有原发性恶性肿瘤的患者可能会患上自身免疫性疾病。这些关系意味着需要对接受免疫调节治疗的患者进行监测，以预防潜在的继发性疾病过程。
