Department of Surgical Sciences, Section of Surgery, Uppsala University, Uppsala, Sweden.
Anticancer Res. 2012 Apr;32(4):1443-8.
The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP.
Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables.
The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04).
The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.
本研究的目的是：i）评估一种新的、更详细的组织病理学分类，并分析病理学家在假黏液瘤腹膜（PMP）的组织病理学分类中的一致性；ii）分析基质中特别有趣的新半胱氨酸-组氨酸（PINCH）蛋白的表达及其在 PMP 中的预后意义。
对 81 例患者的手术标本进行了研究，这些患者根据 Ronnett 等人的组织病理学分类进行了分类，并与新的系统进行了比较，该系统有四个组，从惰性到侵袭性生长模式。分析了 PINCH 蛋白的表达，并将其与临床变量相关联。
新的四组分类比 Ronnett 等人的分类提供了更好的预后信息（p=0.04）。在 83%的病例中发现了基质中 PINCH 蛋白的表达，与高肿瘤负荷（p=0.002）和预后不良（p=0.04）相关。
提出的新 PMP 分类系统可能提供额外的预后信息。PINCH 蛋白在 PMP 中表达，并具有预后意义。
