[An analysis of pathologic features and prognostic factors of 10 cases with pseudomyxoma peritonei].

OBJECTIVE

To investigate the histogenesis and the pathological features of pseudomyxoma peritonei and to analysis its prognostic factors.

METHODS

Ten cases with pseudomyxoma peritonei were clinicopathologically studies, with follown-up at least 24 monthes. All histopathological sections and clinical data were reviewed.

RESULTS

Seven out of 10 patients had the ovarian mucinous tumors which were bilateral in 5 cases (71.4%). Histopathologically, 4 of 7 cases with ovarian tumor were characterized by the presence of the multifocal bleeding, fragmental necrosis, and occasionally, the striated border on the glandular lumens. The mucinous epithelial cells and mucin invased into the peritonei, destroyed normal structure, and formed the desmoplasia. Four patients died of pseudomyxoma peritonei, all with extensive lesions, invasions in the peritonei, and a short recurrent time (mean, 12.0 monthes) after presentation.

CONCLUSIONS

The histogenesis of pseudomyxoma peritonei is heterogenous, the presence of possible metastases including from the appendix, the colon and other organs. The most important factors of the prognosis should include the extent of initial lesions, the presence of invasion in the peritonei and a rapid recurrence.