Departmento de Medicina y Cirugía Animal, University of Cordoba, Cordoba, Spain.
Vet Q. 2012;32(1):13-6. doi: 10.1080/01652176.2012.677867. Epub 2012 Apr 11.
Donkeys appear to be more predisposed than large breed horses to suffer from hyperlipemia. The reason for that predisposition is unknown but anorexia is a consistent feature of the disease. Leptin, a protein synthesized in fat tissue, is one of the major inhibitors of appetite in mammals.
We hypothesized that donkeys could have elevated plasma leptin concentrations compared to horses.
Blood samples were obtained from 50 donkeys for measurement of leptin, triglycerides (TGs), glucose, and insulin. Glucose/insulin ratio, modified insulin to glucose ratio, and reciprocal of the square root of insulin were calculated. Based on their body condition score (BCS), donkeys were classified as lean (n = 18), normal (n = 16), or overweight (n = 16). The results were compared with reference values from our laboratory and with a group of horses (n = 25) used as an internal control.
Values of both leptin and TGs in donkeys were above the horse reference range and also significantly higher than those of the control horses: leptin (11.2 ± 1.7 versus 5.8 ± 0.5 µg/L, p < 0.05) and TGs (0.93 ± 0.1 versus 0.54 ± 0.1 mmol/L, p < 0.01). Overweight donkeys had leptin (19.3 ± 2.9 µg/L) and TG (1.3 ± 0.2 mmol/L) concentrations that were significantly (p < 0.01) higher than normal (9.4 ± 3.3 µg/L and 0.85 ± 0.1 mmol/L, respectively) and lean (5.5 ± 1.0 µg/L and 0.66 ± 0.1 mmol/L, respectively) donkeys. A significant positive correlation (p < 0.01) was found between BCS and leptin (r = 0.43), TGs (r = 0.46), glucose (r = 0.41), and insulin (r = 0.40).
Donkeys have higher plasma leptin concentrations than horses and leptin is correlated with BCS.
驴似乎比大型马更容易患高脂血症。这种倾向的原因尚不清楚，但厌食是该病的一个一致特征。瘦素是脂肪组织合成的一种蛋白质，是哺乳动物食欲的主要抑制剂之一。
我们假设驴的血浆瘦素浓度可能高于马。
采集 50 头驴的血液样本，用于测量瘦素、甘油三酯 (TGs)、葡萄糖和胰岛素。计算葡萄糖/胰岛素比值、改良胰岛素/葡萄糖比值和胰岛素平方根的倒数。根据体况评分 (BCS)，将驴分为瘦型 (n=18)、正常型 (n=16) 和超重型 (n=16)。将结果与我们实验室的参考值和一组马 (n=25) 进行比较，作为内部对照。
驴的瘦素和 TGs 值均高于马的参考范围，也明显高于马的对照值：瘦素 (11.2±1.7 与 5.8±0.5 μg/L，p<0.05) 和 TGs (0.93±0.1 与 0.54±0.1 mmol/L，p<0.01)。超重的驴的瘦素 (19.3±2.9 μg/L) 和 TG (1.3±0.2 mmol/L) 浓度明显高于正常 (9.4±3.3 μg/L 和 0.85±0.1 mmol/L) 和瘦型 (5.5±1.0 μg/L 和 0.66±0.1 mmol/L) 驴。BCS 与瘦素 (r=0.43，p<0.01)、TGs (r=0.46，p<0.01)、葡萄糖 (r=0.41，p<0.01) 和胰岛素 (r=0.40，p<0.01) 呈显著正相关。
驴的血浆瘦素浓度高于马，瘦素与 BCS 相关。
