Department of Animal Medicine and Surgery, University of Cordoba, Campus Rabanales, 14104 Cordoba, Spain.
Department of Veterinary Clinical Sciences, Ohio State University, 43210 Columbus, OH, USA.
Vet J. 2021 May;271:105652. doi: 10.1016/j.tvjl.2021.105652. Epub 2021 Mar 6.
Metabolic and endocrine disorders, such as dyslipidemia, are common in donkeys. Negative energy balance due to fasting, stressful conditions, or disease is a major trigger for fat mobilization often leading to dyslipidemia. The hormonal response to fasting has not been well characterized in donkeys. Therefore, this work aimed to study variations in insulin, glucagon, leptin, total adiponectin, ghrelin, and insulin-like growth factor-1 concentrations, insulin-to-glucagon (IGR) and glucagon-to-insulin (GIR) molar ratios, and lipid and carbohydrate parameters during a 66 h fasting period in 8 adult donkeys, and to determine differences depending on body condition. Obese donkeys developed earlier lipid mobilization (increased plasma total triglyceride and total cholesterol concentrations) compared to non-obese donkeys. Plasma glucose and leptin concentrations decreased in obese animals. After 60 h fasting, obese donkeys showed a significant increase in glucagon and decrease in leptin. GIR significantly increased, while insulin and IGR decreased in both groups. These findings support faster lipid mobilization in response to negative energy status in obese donkeys during fasting, which could be linked to greater glucagonemia and could explain the predisposition of these animals to dyslipidemia.
代谢和内分泌紊乱，如血脂异常，在驴中很常见。由于禁食、应激条件或疾病导致的负能平衡是脂肪动员的主要触发因素，常导致血脂异常。驴的禁食激素反应尚未得到很好的描述。因此，本研究旨在研究 8 头成年驴在 66 小时禁食期间胰岛素、胰高血糖素、瘦素、总脂联素、胃饥饿素和胰岛素样生长因子-1 浓度、胰岛素与胰高血糖素（IGR）和胰高血糖素与胰岛素（GIR）摩尔比以及脂质和碳水化合物参数的变化，并确定这些变化与体况有关。与非肥胖驴相比，肥胖驴更早出现脂质动员（血浆总甘油三酯和总胆固醇浓度增加）。肥胖动物的血糖和瘦素浓度下降。禁食 60 小时后，肥胖驴的胰高血糖素显著升高，瘦素降低。两组的 GIR 均显著增加，而胰岛素和 IGR 均降低。这些发现支持肥胖驴在禁食期间对负能状态的更快脂质动员，这可能与更高的胰高血糖素血症有关，并解释了这些动物易发生血脂异常的倾向。
