Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
Brain Res. 2012 Oct 2;1476:132-53. doi: 10.1016/j.brainres.2012.03.035. Epub 2012 Mar 23.
The present review provides an overview on serotonin (5-hydroxytryptamine; 5-HT)(2C) receptors and their relationship to drug dependence. We have focused our discussion on the impact of 5-HT(2C) receptors on the effects of different classes of addictive drugs, illustrated by reference to data using pharmacological and genetic tools. The neurochemical mechanism of the interaction between 5-HT(2C) receptors, with focus on the mesocorticolimbic dopaminergic system, and drugs of abuse (using cocaine as an example) is discussed. Finally, we integrate recent nonclinical and clinical research and information with marketed products possessing 5-HT(2C) receptor binding affinities. Accordingly, available nonclinical data and some clinical observations targeting 5-HT(2C) receptors may offer innovative translational strategies for combating drug dependence.This article is part of a Special Issue entitled: Brain Integration.
本综述概述了 5-羟色胺（5-羟色胺；5-HT）（2C）受体及其与药物依赖的关系。我们的讨论重点是 5-HT（2C）受体对不同类别的成瘾性药物的影响，参考了使用药理学和遗传学工具的数据。讨论了 5-HT（2C）受体与滥用药物（以可卡因为例）之间的神经化学相互作用的机制，重点是中脑边缘多巴胺能系统。最后，我们整合了最近的非临床和临床研究以及具有 5-HT（2C）受体结合亲和力的上市产品的信息。因此，针对 5-HT（2C）受体的现有非临床数据和一些临床观察结果可能为对抗药物依赖提供创新的转化策略。本文是特刊“大脑整合”的一部分。
