抗 CD45RB/抗 TIM-1 诱导的耐受需要调节性 B 细胞。
Anti-CD45RB/anti-TIM-1-induced tolerance requires regulatory B cells.
机构信息
Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Am J Transplant. 2012 Aug;12(8):2072-8. doi: 10.1111/j.1600-6143.2012.04055.x. Epub 2012 Apr 11.
Abstract
The role of B cells in transplant tolerance remains unclear. Although B-cell depletion often prolongs graft survival, sometimes it results in more rapid rejection, suggesting that B cells may have regulatory activity. We previously demonstrated that tolerance induction by anti-CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in combination with anti-TIM-1 antibody has a synergistic effect, inducing tolerance in all recipients in a mouse islet allograft model. This effect depends on the presence of recipient B cells, requires B-cell IL-10 activity, and is antigen-specific. These data suggest the existence of a regulatory B-cell population that promotes tolerance via an IL-10-dependent pathway.
摘要
B 细胞在移植耐受中的作用尚不清楚。虽然 B 细胞耗竭通常会延长移植物的存活时间，但有时也会导致更快的排斥反应，这表明 B 细胞可能具有调节活性。我们之前的研究表明，抗 CD45RB 抗体诱导的耐受需要受体 B 细胞。在这里，我们显示抗 CD45RB 联合抗 TIM-1 抗体具有协同作用，在小鼠胰岛移植模型中诱导所有受体的耐受。这种作用依赖于受体 B 细胞的存在，需要 B 细胞 IL-10 活性，并且具有抗原特异性。这些数据表明存在一种调节性 B 细胞群体，通过 IL-10 依赖途径促进耐受。
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