Cao Jinmeng, Qing Jilin, Zhu Liya, Chen Zhizhong
Joint Inspection Center of Precision Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region and Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.
School of Clinical Medicine, Guilin Medical University, Guilin, Guangxi, China.
Front Cell Dev Biol. 2024 May 20;12:1307806. doi: 10.3389/fcell.2024.1307806. eCollection 2024.
T-cell immunoglobulin and mucin structural domain 1 (TIM-1, also known as hepatitis A virus cell receptor 1) is a co-stimulatory molecule that is expressed predominantly on the surface of T cells. TIM-1 promotes the activation and proliferation of T cells, cytokine secretion, and can also be overexpressed in various types of cancer. Upregulation of TIM-1 expression may be associated with the development and progression of cancer. After reviewing the literature, we propose that TIM-1 affects tumour development mainly through two pathways. In the Direct pathway: overexpression in tumours activates tumour-related signaling pathways, mediates the proliferation, apoptosis, invasion and metastasis, and directly affects tumour development directly. In the indirect pathway: In addition to changing the tumour microenvironment and influencing the growth of tumours, TIM-1 binds to ligands to encourage the activation, proliferation, and generation of cytokines by immune cells. This review examines how TIM-1 stimulates the development of tumours in direct and indirect ways, and how TIM-1 is exploited as a target for cancer therapy.
T细胞免疫球蛋白和粘蛋白结构域1（TIM-1，也称为甲型肝炎病毒细胞受体1）是一种共刺激分子，主要在T细胞表面表达。TIM-1促进T细胞的活化和增殖、细胞因子分泌，并且在各种类型的癌症中也可能过表达。TIM-1表达上调可能与癌症的发生和发展有关。在回顾文献后，我们提出TIM-1主要通过两条途径影响肿瘤发展。在直接途径中：在肿瘤中过表达激活肿瘤相关信号通路，介导增殖、凋亡、侵袭和转移，并直接影响肿瘤发展。在间接途径中：除了改变肿瘤微环境并影响肿瘤生长外，TIM-1与配体结合以促进免疫细胞的活化、增殖和细胞因子生成。本综述探讨了TIM-1如何以直接和间接方式刺激肿瘤发展，以及TIM-1如何被用作癌症治疗的靶点。
