Human Development and Health Academic Unit, University of Southampton, Southampton SO16 6YD, United Kingdom.
Prostaglandins Leukot Essent Fatty Acids. 2012 Apr;86(4-5):141-7. doi: 10.1016/j.plefa.2012.03.007. Epub 2012 Apr 9.
The mechanisms responsible for changes to long-chain polyunsaturated fatty acid (LC PUFA) status during pregnancy have not been fully elucidated. Tissue samples were collected from virgin and pregnant (day 12 and 20) female rats. LC PUFA status, sex hormone concentrations and hepatic mRNA expression of FADS1, FADS2 and elongase were assessed. Day 20 gestation females had higher plasma and liver docosahexaenoic acid and lower arachidonic acid content than virgin females (P<0.05). There was higher FADS2 mRNA expression during pregnancy (P=0.051). Progesterone and oestradiol concentrations positively correlated with hepatic FADS2 mRNA expression (P=0.043, P=0.004). Progesterone concentration positively correlated with hepatic n-6 docosapentaenoic acid content (P=0.006), and inversely correlated with intermediates in LC PUFA synthesis including n-3 docosapentaenoic acid, γ-linolenic acid and 20:2n-6 (P<0.05). Changes in progesterone and oestradiol during pregnancy may promote the synthesis of LC PUFA via increased FADS2 expression.
导致妊娠期间长链多不饱和脂肪酸 (LC PUFA) 状态变化的机制尚未完全阐明。从处女和妊娠（第 12 天和第 20 天）雌性大鼠中采集组织样本。评估 LC PUFA 状态、性激素浓度以及 FADS1、FADS2 和延伸酶的肝 mRNA 表达。与处女雌性相比，妊娠第 20 天的雌性具有更高的血浆和肝脏二十二碳六烯酸含量和更低的花生四烯酸含量（P<0.05）。妊娠期间 FADS2 mRNA 表达更高（P=0.051）。孕酮和雌二醇浓度与肝 FADS2 mRNA 表达呈正相关（P=0.043，P=0.004）。孕酮浓度与肝 n-6 二十二碳五烯酸含量呈正相关（P=0.006），与 LC PUFA 合成中的中间产物呈负相关，包括 n-3 二十二碳五烯酸、γ-亚麻酸和 20:2n-6（P<0.05）。妊娠期间孕酮和雌二醇的变化可能通过增加 FADS2 表达来促进 LC PUFA 的合成。
