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[自由基过程抑制剂对眼色素上皮黑素蛋白颗粒“暗”顺磁中心的影响]

[Effect of inhibitors of free radical processes on the "dark" paramagnetic centers of the melanoprotein granules of the pigment epithelium of the eye].

作者信息

Sakina N L, Pulatova M K, Ostrovskiĭ M A, Smirnov L D

出版信息

Biofizika. 1979 Jul-Aug;24(4):646-50.

PMID:224951
Abstract

Effect of three inhibitors of free radical processes (IFRP) differing in antiradical activity (2-tret. butyl-6-methyl-3-oxipyridin, 2-ethyl-6-methyl-3-oxipyridin and 3-oxipyridin) on paramagnetic centres of melanoprotein granules of pigment epithelium was studied by ESR method at room temperature. It was shown that IFRP decreased the dark signal and that the reaction of paramagnetic particles dissociation proceeded according to the equation of the first order reaction. The rate constants of these reactions were calculated. It was found that the relative amount of reacting and non-reacting paramagnetic particles with the inhibitor depended on the nature and concentration of IFRP.

摘要

采用电子自旋共振(ESR)方法,在室温下研究了三种具有不同抗自由基活性的自由基过程抑制剂(IFRP)(2-叔丁基-6-甲基-3-氧化吡啶、2-乙基-6-甲基-3-氧化吡啶和3-氧化吡啶)对色素上皮黑素蛋白颗粒顺磁中心的影响。结果表明,IFRP降低了暗信号,顺磁颗粒解离反应按照一级反应方程进行。计算了这些反应的速率常数。发现与抑制剂发生反应和未发生反应的顺磁颗粒的相对量取决于IFRP的性质和浓度。

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