Stansell L, Smith E, Kirsch A
Children's Healthcare of Atlanta, Atlanta, GE, USA.
Minerva Pediatr. 2012 Apr;64(2):183-95.
It has been nearly fifty years since J.M. Smellie published a seminal work that changed the landscape of vesicoureteral reflux when he reported the outcomes of 116 children with chronic pyelonephritis and the benefits of chemoprophylaxis. Even then, he conceded "the effectiveness of any form of treatment will be known only after prolonged follow-up". Forty-six years later, the answers to many questions remain elusive. The surfeit of available information continues to provoke controversy - from the presentation of reflux to the management thereof. We endeavor to survey the rocky landscape of vesicoureteral reflux and provide a critical appraisal of the available evidence and challenges for the future.
自J.M. 斯梅利发表了一项开创性的研究成果以来，已经过去了近五十年。当时他报告了116例慢性肾盂肾炎患儿的治疗结果以及化学预防的益处，这一研究改变了膀胱输尿管反流的研究格局。即便在那时，他也承认“任何形式治疗的有效性只有经过长期随访才能知晓”。四十六年后，许多问题的答案仍然难以捉摸。大量可得信息持续引发争议——从反流的表现到其治疗方法。我们试图审视膀胱输尿管反流这一崎岖领域，并对现有证据以及未来面临的挑战进行批判性评估。
