Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Bioinformatics. 2012 May 15;28(10):1411-2. doi: 10.1093/bioinformatics/bts157. Epub 2012 Apr 11.
Transcription and chromatin regulators, and histone modifications play essential roles in gene expression regulation. We have created CistromeMap as a web server to provide a comprehensive knowledgebase of all of the publicly available ChIP-Seq and DNase-Seq data in mouse and human. We have also manually curated metadata to ensure annotation consistency, and developed a user-friendly display matrix for quick navigation and retrieval of data for specific factors, cells and papers. Finally, we provide users with summary statistics of ChIP-Seq and DNase-Seq studies.
转录和染色质调节因子以及组蛋白修饰在基因表达调控中发挥着重要作用。我们创建了 CistromeMap 作为一个网络服务器，提供了在小鼠和人类中所有公开的 ChIP-Seq 和 DNase-Seq 数据的综合知识库。我们还手动整理了元数据，以确保注释的一致性，并为特定因子、细胞和论文的数据的快速导航和检索开发了用户友好的显示矩阵。最后，我们为用户提供了 ChIP-Seq 和 DNase-Seq 研究的汇总统计信息。
