Radiotherapy Department, Integrated Center of Oncology, René Gauducheau, St. Herblain, France.
Head Neck. 2013 Mar;35(3):350-3. doi: 10.1002/hed.22981. Epub 2012 Apr 12.
Infiltrating squamous cell carcinoma (SCC) of the lower lip is a highly curable cancer. We retrospectively analyzed oncologic, functional, and cosmetic outcomes after interstitial low-dose rate brachytherapy at 58 Gy (50-62) of lower lip SCC treated in our institution.
There were 89 patients (44 T1, 33 T2, 2 T3, and 10 after wedge-excision). All tumors were N0 at the time of treatment. We calculated survival rates and assessed functional and cosmetic results de visu.
After a median follow-up of 36 months (range, 9-127), 5-year local control rate was 95% and 5-year disease-free survival was 82%. Only 6 patients (5 T2 and 1 T3) developed secondary cervical nodal involvement. Sixty-one patients were reassessed and 11 patients presented mild functional troubles. Cosmetic results were good (77%) or fair (21%).
Brachytherapy provided a high local disease control rate, excellent functional results, and good cosmetic outcomes for SCCs of the lip. Risk of cervical node involvement was low with small tumors.
下嘴唇浸润性鳞状细胞癌（SCC）是一种高度可治愈的癌症。我们回顾性分析了在本机构接受 58 Gy（50-62）间质低剂量率近距离放疗治疗的下嘴唇 SCC 的肿瘤学、功能和美容结果。
共 89 例患者（44 例 T1、33 例 T2、2 例 T3 和 10 例楔形切除术后）。所有肿瘤在治疗时均为 N0。我们计算了生存率，并通过肉眼评估了功能和美容结果。
中位随访 36 个月（范围 9-127）后，5 年局部控制率为 95%，5 年无病生存率为 82%。仅有 6 例患者（5 例 T2 和 1 例 T3）出现继发性颈淋巴结转移。61 例患者进行了重新评估，其中 11 例患者出现轻度功能障碍。美容效果良好（77%）或尚可（21%）。
对于嘴唇 SCC，近距离放疗提供了较高的局部疾病控制率、良好的功能结果和良好的美容效果。对于小肿瘤，颈淋巴结受累的风险较低。
