Orecchia R, Rampino M, Gribaudo S, Negri G L
Radiotherapy Department of the University of Turin, Italy.
Tumori. 1991 Aug 31;77(4):336-8. doi: 10.1177/030089169107700409.
From 1973 to 1988 47 patients with previously untreated T1 and T2 squamous cell carcinomas of the lower lip received a definitive course of interstitial brachytherapy by iridium 192 wires. The disease stage was T1 in 21 cases (44.7%) and T2 in 26, and N0 in all cases except 2 of N1. Radiation therapy dose ranged between 6000 and 8000 cGy. Local control was obtained in 44 patients (93.6%). Treatment failure in the neck was observed in 3 patients (6.7%). The 5- and 10-year actuarial disease-free survival rates were 92% and 85%, respectively. A surgical salvage was attempted in 3 patients, with postoperative definitive control of the disease in 2. The 10-year actuarial overall survival was 95%. The incidence of complications was acceptable (10.6% of mucosal necrosis). An excellent or good cosmetic result was obtained in 91.7% of patients.
1973年至1988年，47例初治的下唇T1和T2期鳞状细胞癌患者接受了192铱线组织间近距离放射治疗的完整疗程。疾病分期为T1期21例（44.7%），T2期26例，除2例N1外，所有病例均为N0。放射治疗剂量在6000至8000 cGy之间。44例患者（93.6%）获得局部控制。3例患者（6.7%）出现颈部治疗失败。5年和10年精算无病生存率分别为92%和85%。3例患者尝试手术挽救，其中2例术后疾病得到最终控制。10年精算总生存率为95%。并发症发生率可以接受（黏膜坏死发生率为10.6%）。91.7%的患者获得了优良或良好的美容效果。
