Department of Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, UK.
Mult Scler. 2012 Dec;18(12):1801-3. doi: 10.1177/1352458512443994. Epub 2012 Apr 11.
In a recent study, administration of granulocyte colony stimulating factor (G-CSF) increased neuromyelitis optica (NMO) lesions in mice. Here we report a patient whose first episode of NMO may have been exacerbated by inadvertent administration of G-CSF. Histological examination of brain and spinal cord samples from three other NMO patients revealed markedly increased expression of G-CSF in neurons located in and around the lesions, with little or no expression in multiple sclerosis lesions or normal white matter. Taken together, these cases support a detrimental role for G-CSF in NMO pathogenesis.
在最近的一项研究中，粒细胞集落刺激因子（G-CSF）的给药增加了视神经脊髓炎（NMO）在小鼠中的病变。在这里，我们报告了一名患者，他的首次 NMO 发作可能因意外给予 G-CSF 而加重。对另外三名 NMO 患者的脑和脊髓样本进行的组织学检查显示，位于病变部位及周围的神经元中 G-CSF 的表达显著增加，而在多发性硬化病变或正常白质中则很少或没有表达。综上所述，这些病例支持 G-CSF 在 NMO 发病机制中起有害作用。
